Top 10 Benefits of Agmatine Sulfate Supplements
Agmatine sulfate is released by the body to assist with functions in the central nervous system, primarily as a neurotransmitter and neuromodulator.
Research into agmatine shows that it has potential to help your body in a variety of ways - from assisting with pain relief and reducing depression, to increasing insulin sensitivity and aiding muscle growth.
As such, supplementing with agmatine could hold the key to improved physical and mental health.
Read on to find out more about the top ten agmatine sulfate benefits.
1. Pain Relief
One of the key benefits of agmatine is that it reduces pain through the release of natural opioid compounds. As well as providing short-term pain relief, agmatine also shows potential to reduce perceived pain.
Specifically, agmatine targets the pain caused by inflammation. Research on participants suffering from a herniated lumbar disk showed that agmatine minimized pain and improved quality of life.
As a training supplement, agmatine can lead to a faster post-workout recovery and improved physical performance through reduced pain perception.
2. Appetite Stimulation
Agmatine also helps to improve appetite, even after reaching satiety. Rats given agmatine consumed as much as 54 percent more food over a 24-hour period.
While this is listed here as a benefit, it is also considered one of the main agmatine sulfate side effects.
But, for those who find it hard to achieve weight gain, supplementing with agmatine could help them overcome this issue. And, when combined with weight-lifting, this would aid muscle growth, which is often difficult for 'hard gainers'.
3. Muscle Growth
For training purposes, the most important of all the agmatine benefits is its role in building muscle.
In fact, most agmatine supplements focus on pump inducement and the process of promoting muscle, and list the agmatine sulfate dosage accordingly. Intake recommendations range between 1.6 and 6.4 mg of agmatine per kilogram of body weight.
Agmatine helps promote muscle growth by stimulating the production of luteinizing hormone (LH). Increased LH levels result in increased levels of testosterone. This creates an optimal hormonal environment for improved athletic performance and muscle growth.
By playing a role in regulating nitric oxide synthase (NOS), agmatine also increases vasodilation, improving muscle pumps. This then allows muscles to take in more nutrients, glucose and amino acids. These are all crucial for muscle tissue growth and repair.
4. Insulin and Blood Sugar Levels
Agmatine improves insulin sensitivity and helps to reduce blood sugar levels.
By activating imidazoline receptors, agmatine helps reduce the amount of glucose in the blood. This, in turn, causes an increase in endorphins. And, more endorphins mean a greater intake of glucose and amino acids by muscle tissue, even during periods of inactivity.
As such, this improved insulin response shows how agmatine supplements can help individuals achieve a leaner physique while gaining grater muscle mass.
5. Alzheimer's Disease
By improving insulin sensitivity, agmatine can also prevent the cognitive decline associated with Alzheimer's disease.
Insulin sensitivity can result in the accumulation of amyloid plaques and neurofibrillary tangles in the brain, both signs of Alzheimer's disease. Agmatine prevented cognitive decline in the brains of rats by regulating insulin signals and stopping the formation of plaques and tangles.
6. Stress, Anxiety and Depression
Agmatine has also been found to eliminate depressive symptoms, and plays a role in reducing anxiety and the negative effects of stress.
By increasing NRF2 (a basic leucine zipper protein), agmatine protects brain cells from the stress hormone cortisol. This helps to prevent depressive behavior.
Depression is also linked to low adenylate cyclase levels and a decrease of monoamines, e.g. dopamine. Agmatine increases adenylate cyclase levels and helps block NMDA receptors to prevent the decrease of monoamines.
The body produces more agmatine during periods of stress as a protective measure. Agmatine supplements can help enhance this effect, helping the body to combat the negative impact of stress and reduce anxiety. This also allows the body to regulate cortisol levels, helping to improve over health as a result.
By reducing stress, anxiety and depression, agmatine improves focus, and leads to an enhanced state of well-being. It also enhances motivation to pursue personal objectives such as better health and fitness.
7. Memory and Mental Clarity
Agmatine has also been found to improve mental focus and memory.
Agmatine does not appear to aid memory retrieval. But, it does play a role in helping the brain accurately record and store memory in the first place.
The body produces more agmatine during spatial learning tasks. And, as a neurotransmitter, agmatine is associated with memory formation. Plus, agmatine aids memory formation by increasing adenylate cyclase activity in the prefrontal cortex.
Agmatine also stimulates the formation of new brain cells, resulting in improved mental clarity and focus.
8. Blood Pressure
By widening the blood vessels, agmatine helps the body maintain a healthier level of blood pressure. This allows for more efficient nutrient delivery, improving overall health and enhances the body's ability to grow muscle.
But, this minor drop in blood pressure may not be desirable for those undergoing treatment for hypotension (low blood pressure). So, this benefit may also be seen as one of the agmatine sulfate side effects.
9. Stroke Damage
By regulating NOS, agmatine protects the brain by dilating the blood vessels to increase blood flow. This helps to prevent brain damage when oxygen cannot reach the brain due to reduced blood flow, such as during a stroke.
As such, agmatine shows potential as a pre-treatment for stroke-related neurological damage. Meaning that agmatine supplements may be beneficial for those who are at risk of a stroke.
10. Tumor Growth
Studies into agmatine have also shown that it inhibited the growth of tumors and tumor cells in mice. This is due to the way it reduces the level of polyamines - molecules thought to be involved in tumor growth.
The Benefits of Agmatine Sulfate
More research is necessary for a better understanding of how agmatine works and to what extent.
But, as these benefits show, agmatine sulfate has a lot of potential, both as a training supplement, and as a means to prevent or reduce a range of medical conditions.
For more information and advice on supplements and training methods, check out our other blog posts. And, don't forget to sign up to our newsletter for all the latest news and offers!