Muscle Research’s T-Base (Testosterone-Base) is a topical pro-steroid cream that combines precise amounts of DHEA (dehydroepiandrosterone, 3b-hydroxyandrost-5-en-17-one) and 1-DHEA (1-Androsterone, 3b-Hydroxy-Androst-1-ene-17-one), along with anti-estrogens, a neurosteroid and DHT inhibitor. These active ingredients are immediately delivered directly to the blood stream via T-Base’s advanced transdermal delivery system. Our unique transdermal delivery system enhances the absorption, uptake and efficiency of the ingredients in T-Base, making it up to 20 times more effective than oral supplements (tablets/capsules). This in turn, enhances performance, increases lean muscle, increases strength, reduces body fat and improves overall body composition. Advantage, YOU! If you are supplementing DHEA, or thinking of supplementing DHEA, you want to be sure to use a transdermal preparation. Studies have shown that transdermal DHEA has a relatively high bioavailability. In fact, oral DHEA only has 10-15% of the bioavailable activity as the transdermal DHEA in T-Base! If you are supplementing with Oral DHEA, you are wasting a large amount of hormones and you are throwing money away. The advanced transdermal delivery system in T-Base ensures your body converts a much higher amount of anabolic and androgenic hormones. This is why you want T-Base! T-Base is one of the most powerful prohormone products legally available today. Even a 5 week cycle of T-Base can provide significant gains in size and strength. A user could expect gains of up to 6 to 10 pounds (or more) of lean body mass, with little to no side effects due to the specific combination of ingredients to block estrogen and control DHT. Most people are familiar with DHEA (androstenolone). DHEA and its supplementation in humans, has been studied for decades. DHEA is the body’s natural steroid hormone precursor. Powerful anabolic and androgenic hormones, such as androstenediol, androstenedione and testosterone are converted from DHEA. DHEA has been used by the anti-aging crowd as early as the 1980’s, for its abilities to increase strength and energy, burn fat, improve libido and sexual performance, promote an enhanced sense of well-being, improve recovery from exercise and immune system function, and provide a noticeable improvement in body composition, even without changes in diet or exercise. Though T-Base’s transdermal preparation provides the highest level of hormone bioavailability, DHEA still converts to testosterone at a relatively low rate. DHEA does have a high conversion to 5-androstenediol, which is where it gets most of its mild androgenic and anabolic effects. DHEA’s thermogenic fat burning properties come from its conversion to 7-oxo-DHEA. DHEA rarely causes hair loss or acne, and although it has moderate estrogenic effects, it rarely produces gynecomastia (gyno) or other unwanted estrogenic side effects. Transdermal DHEA applications have actually shown in studies to have no significant increase in serum estrogens. Studies using oral DHEA however, have shown significant increase in circulating estrogens. The inclusion of anti-estrogens and a DHT inhibitor in T-Base further reduces any probability of these negative side effects. T-Base has you covered! 1-DHEA (1-Androsterone) is a pro-steroid that must convert to one of the highly anabolic and androgenic, 1-androstenediol (1-AD), 1-androstenedione (original 1-AD) and/or 1-testosterone to be active. T-Base’s transdermal delivery system improves these conversions due to the high concentration of steroidogenic enzymes in the skin compared to the digestive tract. Once in its final form, this compound has about the same androgenic potency of testosterone, with twice the anabolic potency (100:200 vs 100:100). 1-DHEA primarily converts to the potent 1-androstenediol (1-AD), and it does not convert to estrogen nor does it activate the estrogen receptor. It is noted for producing moderate gains of lean muscle mass and strength, increased muscle hardness, enhanced recovery, more intensive workouts, and a slight decrease in body fat. 1-DHEA is a naturally occurring, non-toxic, safe, legal and effective lean muscle building agent. It is a “dry” compound, meaning that it does not produce water retention or bloat, nor is it likely to have a dramatic effect on blood pressure. Users should not experience gynecomastia since there is no conversion to estrogen. Reports of hair loss or thinning are minimal with 1-DHEA, and practically non-existent with T-Base’s inclusion of anti-estrogens and a DHT inhibitor. Probably the most common side effect users have reported with 1-DHEA is a feeling of lethargy. However, with the anti-lethargic effects of DHEA and Pregnenolone in T-Base, this 1-DHEA side effect should be eliminated. T-Base’s transdermal delivery system also eliminates liver first pass, providing relief from the worries of liver stress. T-Base also includes the hormone Pregnenolone, the “grandmother” or primary hormone to all hormones. Pregnenolone cream is often prescribed as part of a HRT regimen, to control DHT conversion and help prevent hair loss in men prone to androgenic alopecia. Pregnenolone is also a powerful neurosteroid. In conjunction with DHEA, Pregnenolone further enhances cognitive effects, focus, memory and sense of well-being. A composite of the anti-estrogen ingredients resveratrol, 7,8 benzoflavone and chrysin, round off the active formula of T-Base. These natural compounds can bind to the estrogen receptor and block estrogenic activity. Resveratrol, 7,8 benzoflavone and chrysin have also been shown to support healthy blood vessel function, improve libido, increase testosterone levels, fertility, and erection strength. What kind of results can I expect from T-Base? Results from T-Base can begin to be felt within a few days and become more pronounced and noticeable within a couple of weeks. Of course results will vary based upon the dosage and the user’s experience, diet, rest and effectiveness of workouts. T-Base users can expect enhanced cognitive effects, focus, memory and sense of well-being, increased energy and strength, improved libido, sexual performance, and erection strength, moderate gains of lean muscle mass, increased muscle hardness, enhanced recovery, more intensive workouts, decrease in body fat, and a noticeable improvement in body composition. • May Increase Lean Muscle Mass • May Increase Strength and Energy • May Increase Muscle Density and Fullness • May Increase Fat Loss • May Improve Muscle Recovery • May Enhance cognitive Effects, Focus and Memory • May improve libido, sexual performance, and erection strength • May Improve Sense of Well-Being What is in T-Base? 1 pump per serving 69 servings per bottle: DHEA 75mg 1-Andro, 3b-Hydroxy-Androst-1-ene-17-one 50mg 7,8-Benzoflavone 36mg Resveratrol 36mg Pregnenolone 18mg Chrysin 9mg Ethyl Alcohol Benzophenone-4 Carbomer Fragrance Glycerin Isopropyl Myristate Propylene Glycol Tocopheryl Acetate Water Do I need Post Cycle Therapy after using T-Base? YES. A full PCT is always recommended when using T-Base, since it is supplying the body with an outside source of hormones, and suppressing the body’s natural production of hormones. We recommend the Perfect Post Cycle Therapy Stack, by MR Supps. What side effects can I get when using T-Base? Side effects with T-Base should be mostly non-existent due to the completeness of the formula. Aside from the suppression of your body's natural hormone production, using T-Base within the recommend dose is safe for men, granted there are no serious pre-existing medical conditions. The most likely side effects that could be reported would possibly be skin irritation and/or mild anxiety. These side effects are not very likely, and any mild anxiety should generally be avoidable if the user is participating in moderate physical activity on a daily basis. If any side effects do occur, use of T-Base can be stopped or reduced and the side effects should disappear quickly. There is a risk of T-Base transfer to others who come in contact with the application site for up to 12 hours after application. Secondary exposure can be mitigated by means of a t-shirt barrier. Do I need an AI (Aromatase Inhibitor) when using T-Base? Typically, no you do not. T-Base has an anti-estrogen complex built into the formula. When building a cycle and a PCT, it is always wise to have an AI handy. We highly recommend our extremely potent and effective Forma Stanzol v3, not only for on cycle support, but for use in PCT, to enhance recovery by stimulating LH, FSH and natural testosterone production. Will taking T-Base give me gyno? Since T-Base does not convert to estrogen and has estrogen blockers built into the formula, gynecomastia (gyno) should not be a major concern. If you are highly prone to Gyno it is suggested to use Forma Stanzol v3 for the entire cycle. Is T-Base liver toxic? T-Base is a transdermally applied product that contains non-methylated (non 17aa) pro-steroid ingredients, so it isn’t inherently toxic to the liver. Furthermore, due to the advanced transdermal delivery system, most of the conversions to the anabolic/androgenic hormones such as, 5-androstenediol, 1-androstenediol/1-androstenedione (1-AD) and/or 1-testosterone, are taking place via steroidogenic enzymes in the skin, so liver stress should be virtually eliminated. Studies have also shown no significant elevation in liver enzymes with transdermally applied DHEA hormones. I'm under the age of 21, should I use T-Base? No. In fact, you should not use any steroid or hormonal product if you are under 21. Your body is already making plenty of natural Testosterone at your age and there is no need to mess with hormonal products. I’m an athlete in organized sports, should I use T-Base? No. Using T-Base to enhance athletic performance in competitive sports is morally wrong and against the rules of every known organized sports league. Cheating in sports by a few, is the main reason Steroids are illegal for all of us. Not only are you cheating yourself, but you are also going to get caught. T-Base will make any drug-tested athlete test positive for WADA banned substances during the cycle. What is the recommended usage for T-Base? It is recommended to apply 1 pump twice daily for 5 weeks to upper back, shoulders, or arms. The caliber of effects is dependent on the dose/amount used. It is best to start off with a lighter dose and increase as needed. It is not suggested to apply more than three (3) pumps of T-Base in a 24hr period. More experienced users should feel comfortable experimenting with cycles of up to 8-10 weeks of continuous use of T-Base. In case of accidental overdose, contact a health care professional or poison control center immediately. A PCT is always recommended when using T-Base, since it is supplying the body with an outside source of hormones, and suppressing the body’s natural production of hormones. We recommend the Perfect Post Cycle Therapy Stack, by MR Supps. Research and References: Effects of transdermal application of DHEA to men on the levels of steroids, gonadotropins and lipids. Physiol Res 49: 685-693, 2000. Prohormone supplement 3β-hydroxy-5α-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014 Mar 1;116(5):560-9. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat. J Endocrinol. 1996 Sep;150 Suppl:S107-18. Metabolism of 1-Dehydroandrostanes in Man. Galletti and Gardi, et al. J Steroid Biochem, 3 (1972), 933-936 Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab. 1999 Jun;84(6):2170-6. In vivo conversion of dehydroisoandrosterone to plasma androstenedione and testosterone in man. Horton R, et al.J Clin Endocrinol Metab. 1967 Jan;27(1):79-88. In vitro metabolism of androgens in whole human blood. Blaquier et al.Acta Endocrinol (Copenh). 1967 Aug;55(4):697-704. Sex Steroid Metabolism in Human Peripheral Blood Mononuclear Cells Changes with Aging. J Clin Endocrinol Metab. 2005 Nov;90(11):6283-9. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J Endocrinol. 2000 Feb;164(2):161-9. Transformation in vitro of [4-14C ] dehydroepiandrosterone into 7-oxygenated derivatives by the normal human male and female skin tissue. J. Invest. Dermatol. 52:357. 1969. Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol, May 1, 2001; 116(5): 793-800. Transformation and conjugation of dehydroepiandrosterone by human skin. J. Clin. Endocrinol. 27:1214. 1967. The formation of water soluble steroids by human skin. J. Invest. Dermatol. 50:220. 1968 Pharmacokinetics of a new testosterone transdermal delivery system, TDS-testosterone in healthy males. Br J Clin Pharmacol, Mar 2006; 61(3): 275-9. The in vitro metabolism of dehydroepiandrosterone in human skin. Acta Med Acad Sci Hung, Jan 1967; 23(2): 169-79. The metabolism of [4-14C] dehydroepiandrosterone by human skin in vitro. I. Transformation in vitro of [4-14C] dehydroepiandrosterone into Androst-4-ene-3,17-dione, testosterone and androsterone by normal human male and female skin slices. Acta Med Acad Sci Hung, Jan 1970; 27(1): 95-102. The metabolism of [4-14C] 5 androstene-3P, 17P-diol by normal human skin in vitro. Acta Med. Acad. Sci. Hung. 32:139. 1975. Androgens and anabolic agents Julius A. Vida Chemistry and pharmacology (1969) Seized designer supplement named “1-Androsterone” identification as 3b-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Maria K et al., Steroids. 2011 Feb 16. Circulating bioactive androgens in midlife women. Chen et al. J Clin Endocrinol Metab. 2006 Nov;91(11):4387-94. Epub 2006 Aug 29. Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol. Chen Fet al. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):247-57. Direct agonist/antagonist functions of dehydroepiandrosterone. Chen et al. Endocrinology. 2005 Nov; 146(11):4568-76. Epub 2005 Jun 30 Testosterone metabolism revisited: discovery of new metabolites. Pozo, et al. Anal Bioanal Chem. 2010 Oct;398(4):1759-70. 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties. A Friedel, et al. Toxicol Lett, Aug 2006; 165(2): 149-55. Metabolism of 1-Dehydroandrostanes in Man. Galletti and Gardi, et al. J Steroid Biochem, 3 (1972), 933-936. Serum testosterone levels in non-dosed females after secondary exposure to 1.62% testosterone gel: effects of clothing barrier on testosterone absorption. Curr Med Res Opin. 2012 Feb;28(2):291-301. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry. 1997 Feb 1;41(3):311-8. Double-Blind Treatment of Major Depression With Dehydroepiandrosterone. Am J Psychiatry 1999; 156:646–649. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc Natl Acad Sci USA 92: 6617-6619, 1995. A randomized, double blind, placebo controlled study of 3 - acetyl - 7 - oxo - dehydroepiandrosterone in healthy overweight adults. (2000). Curr. Ther. Res. 61, 435-442. The effect of 7 - keto Naturalean on weight loss: A randomized, double blind placebo controlled trial. (2002). Curr. Ther. Res. 63, 263-272. How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influence thyroid function. Physiol Res, Jan 2006; 55(1): 49-54. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. J Gerontol 1997; 52A:M1- M7. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol. 169:1536-1539. 1993 Novel brain function: biosynthesis and actions of neurosteroids in neurons. Neurosci Res, Apr 2000; 36(4): 261-73. Individual differences in cognitive aging: implication of pregnenolone sulfate. Prog Neurobiol, September 1, 2003; 71(1): 43-8. Memory-Enhancing Effects in Male Mice of Pregnenolone and Steroids Metabolically Derived from it. PNAS, Mar 1992; 89: 1567. Steroid 5alpha-reductase inhibitors. Mini Rev Med Chem, May 1, 2003; 3(3): 225-37 Drug/substance reversal effects of a novel trisubstituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. --a brief perspective. Addiction Biology (December 2003) 8, 379 - 386 Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats. Life Sci, Nov 2002; 71(26): 3059-69. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92 Inhibition of human estrogen synthetase (aromatase) by flavones. Science, Sep 1984; 225: 1032 - 1034. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells. Toxicol. Sci., Jul 2006; 92: 71 - 77. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Me tab 1994;78:1360- 1367. DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells. J Biomed Sci, Mar 2004; 11(2): 200-5. DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. Am J Physiol 1995;268:E107-E113. WARNING KEEP OUT OF REACH OF CHILDREN. This product is intended for adult men only. Not for use by women or anyone under 21 years of age. If you have or have had a medical condition or are currently using prescription drugs consult your physician before using this product. Avoid this product if you have any previous history of medical dysfunction or disease, including but not limited to high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty urinating, prostate enlargement, anxiety, depression, seizure disorder, or have had a stroke. Do not combine this product with other medications or supplements. Do not exceed suggested servings. Consult your health care professional before use if you are taking any prescription drugs. Consult your health care practitioner before beginning any weight loss program. As with any dietary supplement, we recommend that you consult a physician before use. "These statements have not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. ALWAYS consult your physician before taking supplements."